Parr-smolt transformation in Atlantic salmon: thyroid hormone deiodination in liver and brain and endocrine correlates of change in rheotactic behavior
Bibliographic record
Abstract
We tested the hypothesis that metabolism of thyroid hormones by the brain of Atlantic salmon (Salmo salar) changes when rheotactic behavior reverses during parr-smolt transformation (PST). We measured brain and liver thyroxine (T4) and 3,5,3'-triiodo-L-thyronine (T3) outer-ring deiodination (ORD) and inner-ring deiodination (IRD) activities and plasma T4and T3levels in Atlantic salmon held under natural photoperiod in fresh water at 10°C in the spring of 1993 and 1994. We also measured changes in T4, T3, and cortisol levels during the change in rheotactic behavior. Condition factor decreased while salinity tolerance improved from mid-March to late April. The turbidity-induced transition from upstream to downstream swimming occurred in mid to late April. The main changes in brain deiodination were reduced T3IRD (1993 study) and elevated T4ORD (1994 study). In both years, a high ratio of T4ORD/T3IRD activities in the brain indicated an increased potential for T3production in the brain during advanced PST. Liver deiodination profiles differed between years, but during advanced PST the low T4ORD activity and low T4ORD/T3IRD activity ratio suggested a low potential for hepatic, and hence systemic, T3production. However, plasma T4was increased in downstream swimmers at 1 d (1993) and 4 h (1994) after the turbidity increase. Since at this time brain deiodination pathways were poised towards T3production, the surge in plasma T4would likely increase local T3formation in brain. We conclude that during PST there is no major change in hepatic deiodination and hence probably no major change in systemic T3availability. But deiodination properties in brain during late PST indicate the potential for local T3formation. This may be significant when plasma T4increases at the time of downstream migration.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".