Inhibitory Effects of Centrally Administered Somatostatin on the Adrenal Zona glomerulosa in Male Rats
Bibliographic record
Abstract
This study examined the effects of intracerebroventricularly administered somatostatin (SRIF-28 and SRIF-14) on growth and steroidogenic capacity of the rat adrenal zona glomerulosa. Male adult Wistar rats were subjected to intracerebroventricular administration of three 1 microgram doses of SRIF-28 or SRIF-14 every other day. Five days after the last dose, the rats were sacrificed by decapitation. Blood samples were collected for hormonal analyses, and left adrenal glands were taken for histological and morphometric evaluation. In comparison with control animals, the SRIF-treated rats had decreased (p < 0.05) adrenal gland weight and volume. Stereological and morphometric analyses showed decreased (p < 0.05) absolute and relative volumes of the cells and nuclei only in the zona glomerulosa. The plasma levels of aldosterone, growth hormone, and prolactin in both SRIF-treated groups were lower (p < 0.05) than in the control group. The levels of adrenocorticotropic hormone after SRIF treatment did not differ significantly from those in control rats. These findings suggest that centrally administered somatostatin is specifically involved in the control of zona glomerulosa growth and secretion; this effect is probably mediated by inhibiting the secretion of the corresponding pituitary hormones.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".