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Record W2007412389 · doi:10.1109/iembs.2005.1616931

Force enhancement and mechanisms of contraction in skeletal muscle

2005· article· en· W2007412389 on OpenAlexaff
Walter Herzog

Bibliographic record

Venuenot available
Typearticle
Languageen
FieldMedicine
TopicCardiomyopathy and Myosin Studies
Canadian institutionsUniversity of Calgary
Fundersnot available
KeywordsTitinSarcomereMyofibrilMyosinContraction (grammar)Muscle contractionBiophysicsSkeletal muscleActinChemistryAnatomyMyocyteCell biologyBiologyBiochemistryEndocrinology

Abstract

fetched live from OpenAlex

This paper presents a study on force enhancement and mechanisms of contraction in skeletal muscle. Force enhancement was evaluated in four conceptually different experimental preparations: in vivo human muscles activated through voluntary contractions; isolated, in situ muscle preparations (typically the cat soleus), isolated single fibres (typically from the lumbrical muscles of the frog), and isolated single myofibrils (from the rabbit psoas). Results show that force enhancement is caused by an active and passive component. The passive component appears to be associated with sarcomere length and have been speculated to originate within the structural protein, titin. The active component of force enhancement appears to be related to the molecular interaction of actin and myosin, and therefore, seems to be intricately linked to the basic mechanism of contraction

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.001
Scholarly communication0.0000.001
Open science0.0010.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.261
Teacher spread0.251 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2005
Admission routes1
Has abstractyes

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