Subthreshold oscillations of membrane potential of rat subfornical organ neurons
Bibliographic record
Abstract
Previous work has demonstrated that subfornical organ neurons exhibit spontaneous action potentials interspersed with periods of membrane potential oscillation. We used whole cell patch clamp recording to investigate properties of these oscillations. The amplitude, but not the frequency, of the oscillations exhibited voltage dependence. The oscillations were unaffected by application of blockers for gamma-amino-n-butyric acid type A (GABA(A)) and glutamate receptors, nor were they affected by application of Cd2+ to block Ca2+ channels, or Cs+ to block hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels. The oscillations, however, were abolished by the application of tetrodotoxin, indicating a role for voltage-gated Na+ channels. Voltage clamp experiments demonstrated that the activation of persistent Na+ current, but not transient Na+ current, matched with the voltage dependence of activation of the oscillation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".