Isolated Antiphospholipid Syndrome of the Central Nervous System With Positive Lupus Anticoagulant: Two Case Reports
Bibliographic record
Abstract
I present two cases of isolated antiphospholipid syndrome (APS) of the central nerv ous system (CNS) with positive lupus anticoagulant (LA). Both these cases were of the remitting-relapsing type, and optic neuritis and transverse myelitis were not observed. Anticardiolipin antibodies (aCL), anti- ? 2 glycoprotein-I antibodies, and anti-aquaporin-4 antibodies were not detected. Previous reports suggested that both multiple sclerosis (MS) patients with a positive aCL titer and APS patients with an MS-like disease frequently exhibit a neuromyelitis optica-like clinical course and they were positive for aCL but not LA. These results indicate that LA-positive APS and aCL-pos itive APS cases might differ in terms of CNS involvement. doi:10.4021/jmc81w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.009 |
| Meta-epidemiology (narrow) | 0.004 | 0.003 |
| Meta-epidemiology (broad) | 0.001 | 0.002 |
| Bibliometrics | 0.003 | 0.002 |
| Science and technology studies | 0.003 | 0.004 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.002 | 0.003 |
| Research integrity | 0.006 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".