Contribution of the X chromosome to a marked reduction in lifespan in interspecies female hybrids of <i><scp>D</scp>rosophila simulans</i> and <i><scp>D</scp>. mauritiana</i>
Bibliographic record
Abstract
When two species come into contact and interbreed, the production of unfit hybrids can limit or prevent gene flow between the populations, thus maintaining each species' separate identity. The genetic basis of this hybrid dysfunction has recently begun to be elucidated, particularly for hybrid sterility and inviability. Although these dysfunctions can certainly act as a barrier to gene flow, other post-zygotic barriers may also play an important role in isolating species from one another. This study examines the genetic basis of the more subtle mechanism of species isolation via a marked reduction in lifespan of interspecies hybrid offspring. We found that females with homozygous X chromosomes in an otherwise interspecies hybrid background displayed a significant reduction in lifespan; this effect is not due to genetic background and appears to arise from complex genetic interactions. Separately, there is an additional severe reduction in lifespan for attached-X females when they have mated with males of either parental species, which is partly due to interspecific genetic interactions, but primarily due to a female's increased sensitivity to mating when bearing a Y chromosome or the attached-X chromosome construct.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".