Structures of the Glycopeptidolipid Antigens from Serovars in the Mycobacterium avium/Mycobacterium intracellulare/Mycobacterium scrofulaceum Serocomplex
Bibliographic record
Abstract
The 'C-mycosidic' glycopeptidolipid typing antigens from all serovars in the Mycobacterium avium/M. intracellulare/M. scrofulaceum complex have been examined to varying extents. Detailed analysis of those from serovars 8, 9, 16 and 25 show that the antigens consist of short acetylated oligosaccharides linked to a common fattyacyl-peptidyl-O-(3,4-di-O-methylrhamnose) 'core'. The oligosaccharide units, in a form suitable for chemical studies, were liberated as oligosaccharide alditols on treatment of the glycopeptidolipids with alkaline borohydride solution. The alditol in the reduced oligosaccharides from all sources is 6-deoxytalitol. Moreover rhamnose is also always present, indicating that a 'basal' disaccharide, rhamnosyl-6-deoxytalosyl, is always linked to the allo-threonine in the acylpeptide. In addition the oligosaccharides from the glycopeptidolipids of each serovar are distinguished by their own individualistic sugars: 3-O-methylglucose in serovar 8; 2,3-di-O-methylfucose in serovar 9; 2-O-methylfucose in serovar 25; 4-O-methylrhamnose in the oligosaccharide from one of the two glycopeptidolipids in serovar 16 and apparently another rhamnosyl substituent in the other oligosaccharide. The glycopeptidolipid antigens in their structural principals, cellular location and physiological role bear a striking miniscule resemblance to cell wall components of other bacteria such as the O-antigenic and R-antigenic lipopolysaccharides.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".