Arterial adaptations to chronic changes in haemodynamic function: coupling vasomotor tone to structural remodelling
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Healthy mature arteries are usually extremely quiescent tissues with cell proliferation rates much below 1%/day and with extracellular matrix constituents exhibiting half-lives of years to decades. However, chronic physiological or pathological changes in haemodynamic function elicit arterial remodelling processes that may involve substantial tissue synthesis, degradation or turnover. Although these remodelling processes accommodate changing demands placed upon the cardiovascular system by physiological adaptations, they can compromise further perfusion in the context of arterial occlusive disease and they entrench hypertension and may exacerbate its progression. Recent findings indicate that some of the most important such remodelling responses involve the integrated effects of persistently altered vascular tone that feed into restructuring responses, with common signalling pathways frequently interacting in the control of both phases of the response. Current efforts to define these signals and their targets may provide new directions for therapeutic interventions to treat important vascular disorders.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it