NOCTURNAL HEMODIALYSIS [NH] BUT NOT SHORT DAILY HEMODIALYSIS [SDH] REQUIRES AN ELEVATED DIALYSATE CALCIUM CONCENTRATION
Bibliographic record
Abstract
The London Daily/Nocturnal Hemodialysis Study is the first attempt to obtain comparative data of short high efficiency daily HD [SDH] and long slow HU while the patient sleeps [NH] against conventional 3 x/wk HD [CH]. This is a 3-year observational study to follow 40 patients 10 receiving SDH, 10 NH and 20 CH. The CH patients are cohort controls are matched by age, sex, co-morbidity. All patients are followed for 18+ months and treated at home. Enrollment is complete and all have gone 6 months 7 SDH plus 3 NH for 21 months. This report gives data on calcium metabolism. Initially dialysate concentration was 2.5 mEQ/L [1.25 mmol/L]. There were no differences in pre-dialysis corrected calcium [Ca] levels [2.47±0.24 mmol/L M±SD overall]. Post-dialysis Ca levels were lower in NH eg at 1 month SDH Ca was 2.51 ± 0.16 vs NH Ca of 2.31 ± 0.14 [p < 0.00001]. Pre-dialysis phosphate [P] levels were lower in SDH and NH than CH and with NH in P hinders were discontinued. A rise in alkaline phosphatase was seen in NH patients, which peaked at 18 months [NH 191 IU/L±70 SDH 82±34 CH 80±36 p < 0.002] and similarly with intact parrathyroid hormone levels [iPTH] INH 159 pmol±75 SDH 13.1±10 CH 18±18 p < 0.00001]. At 15 months the dialysate Ca concentration was increased to 3.5 mEQ/L [1.75 pmol/LI for the NH patients. Post-dialysis Ca then rose to 2.57±0.21 and alkaline phosphatase and iPTH subsequently normalized. With NH hut not SDH an elevated dialysate Ca concentration is needed.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".