NOCTURNAL HEMODIALYSIS [NH] BUT NOT SHORT DAILY HEMODIALYSIS [SDH] REQUIRES AN ELEVATED DIALYSATE CALCIUM CONCENTRATION
Bibliographic record
Abstract
The London Daily/Nocturnal Hemodialysis Study is the first attempt to obtain comparative data of short high efficiency daily HD [SDH] and long slow HU while the patient sleeps [NH] against conventional 3 x/wk HD [CH]. This is a 3-year observational study to follow 40 patients 10 receiving SDH, 10 NH and 20 CH. The CH patients are cohort controls are matched by age, sex, co-morbidity. All patients are followed for 18+ months and treated at home. Enrollment is complete and all have gone 6 months 7 SDH plus 3 NH for 21 months. This report gives data on calcium metabolism. Initially dialysate concentration was 2.5 mEQ/L [1.25 mmol/L]. There were no differences in pre-dialysis corrected calcium [Ca] levels [2.47±0.24 mmol/L M±SD overall]. Post-dialysis Ca levels were lower in NH eg at 1 month SDH Ca was 2.51 ± 0.16 vs NH Ca of 2.31 ± 0.14 [p < 0.00001]. Pre-dialysis phosphate [P] levels were lower in SDH and NH than CH and with NH in P hinders were discontinued. A rise in alkaline phosphatase was seen in NH patients, which peaked at 18 months [NH 191 IU/L±70 SDH 82±34 CH 80±36 p < 0.002] and similarly with intact parrathyroid hormone levels [iPTH] INH 159 pmol±75 SDH 13.1±10 CH 18±18 p < 0.00001]. At 15 months the dialysate Ca concentration was increased to 3.5 mEQ/L [1.75 pmol/LI for the NH patients. Post-dialysis Ca then rose to 2.57±0.21 and alkaline phosphatase and iPTH subsequently normalized. With NH hut not SDH an elevated dialysate Ca concentration is needed.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".