Effect of Stress and Hypothalamic Deafferentation on the Secretion of Growth Hormone in the Rat
Bibliographic record
Abstract
Stressful stimuli are known to inhibitthe secretion of radioimmunoassayable rat growth hormone (RGH). Groups of adult male rats submitted to one of three different types of hypothalamic deafferentation (total, incomplete, or frontal) were exposed to ether and auditory stresses at 1 week intervals. Ether and auditory stresses were equally effective in inhibiting the RGH secretion in controls and frontally deafferented rats. Ether stress inhibited the RGH values of completely deafferented animals, while auditory stress left these values unchanged; α-MT pretreatment blocked the effect of ether stress in such animals. Neither stress was able to modify the already low values of the incompletely deafferented rats; pentobarbital anesthesia induced a marked rise of RGH plasma levels in these animals. Base-line levels of RGH were significantly higher in frontally deafferented, and significantly lower in incompletely deafferented rats than those of controls. These data seem to indicate that ether stress is transmitted through a humoral, dopa-minergic pathway, while auditory stress follows a nervous pathway. In addition, extra-hypothalamic influences seem to modulate the secretion of RGH through frontal inhibitory and postero-lateral stimulatory nervous pathways.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".