Isolation of Larval Behavioral Mutants in<i>Drosophila Melanogaster</i>
Why this work is in the frame
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Bibliographic record
Abstract
Genetic loci that influence behavior are often difficult to identify and localize in part due to the quantitative nature of behavioral phenotypes. Previous studies had found an association between pupal lethality and altered larval behavior for mutants of several genes. To facilitate the identification and localization of new mutants that influence larval foraging (movement in the presence of food) and general locomotion (movement in the absence of food) behaviors we identified and then screened a collection of strains carrying pupal-lethal mutations for alterations in these larval behaviors. When the lethal mutation segregated with the behavioral alteration this permitted the mapping of the behavioral locus. Nine new loci on the second chromosome were found to affect larval behavior. Of these, seven loci affected foraging and two affected locomotion. Analyses of these new loci will lead to further understanding of the mechanistic bases of larval behavior.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it