?New pressor protein? (NPP) related to $beta;FXIIa stimulates massive catecholamine release from the sympatho-adrenal: is bradykinin a mediator?
Bibliographic record
Abstract
NPP from human plasma is related to βFXIIa. When injected into bioassay rats it raises heart rate, stroke volume and blood pressure, especially systolic BP (SBP). It also provokes massive release of adrenal medullary catecholamines. These effects are potentiated by ACE-inhibition e.g. Captopril (CAP). (J Hypertens 16: 311-320, 1998; Can J Cardiol 18: 1077-1086 and 1093-1103, 2002). Since CAP prevents degradation of bradykinin (BK) we investigated BK as a possible mediator of the cardiovascular effects of injected NPP. NPP (20μL plasma equivalent/rat) was injected i.v. into anesthetized, ganglion blocked (pentolinium) male Wistar bioassay rats (250-350g, n=9) after getting CAP at 10mg/kg (i.v.) and the BK B2-receptor antagonist HOE-140 (20μg/kg, i.v.). Blood pressure (SBP DBP) and heart rate (HR) increments were recorded using a Maclab/8 and PowerMac 7200 computer system. Plasma samples were taken at peak SBP response for determining adrenaline (ADR), noradrenaline (NA) and dopamine (DA) before/after administering HOE-140. HOE-140 markedly reduced pressor HR responses to NPP implicating BK as a mediator of NPP's effects, especially on HR plasma catecholamines. Since all reductions are partial and some (ADR, NA, HR) are more depressed by HOE-140 than others (SBP, DBP, DA), we suggest that BK is not the sole peptidic mediator of NPP's actions, which is also supported by evidence implicating other peptides. There are also questions about BK's direct association with strong pressor effects of NPP, suggesting the need for additional explanation of its mechanism of action. If FXII activation in the body were to generate endogenous NPP it could produce effects similar to those of injected NPP and interfere with ACE-inhibitor therapy. Supported by HSFO grants NA3478, T4136 (See Table) Δ: peak increments over corresponding control baseline values after injecting NPP; Means ± SEM, p<0.05 vs. before HOE-140 Δ: peak increments over corresponding control baseline values after injecting NPP; Means ± SEM, p<0.05 vs. before HOE-140
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".