Synthesis of novel stimuli‐responsive polyglycerol‐based hydrogels
Bibliographic record
Abstract
Abstract Temperature and pH‐responsive polyglycerol‐based hydrogels were successfully synthesized and characterized. An increase in polyglycerol molecular weight was achieved by cross‐linking polyglycerol using multifunctional electrophilic epoxide‐containing compounds. The chemical structure of polyglycerol‐based hydrogels was determined by FTIR spectroscopy. The temperature‐dependent swelling behavior of the hydrogels was studied at 293, 310, 333, and 353 K and a negative temperature‐sensitive system was observed. The hydrogels exhibited pH sensitivity at pH 4, 7, and 10. The hydrophilicity and biocompatibility of these hydrogels make them suitable for pharmaceutical, biomedical, and biotechnological applications. They could potentially serve as a replacement for fossil‐based poly(ethylene glycol) and poly(vinyl alcohol) hydrogels. Practical applications : Polyglycerol produced from glycerol consists of an inert polyether backbone with functional hydroxyl side groups which make it very suitable for the design of hydrogels. The structure of this biocompatible hydrogel resembles well‐known fossil‐based hydrogels poly(ethylene glycol) (PEG) and poly(vinyl alcohol) (PVOH). Polyglycerol‐based hydrogel is suitable for applications in the pharmaceutical, biomedical, and biotechnological fields as drug delivery, tissue engineering, and hydrogel adhesives for wound dressing. Furthermore, since these hydrogels show relatively high swelling ratios, they can be used as moisture absorbents and solvent dryers.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".