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Record W2011118151 · doi:10.1038/ncomms6303

Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk

2014· article· en· W2011118151 on OpenAlexafffund
Sara Lindström, Deborah J. Thompson, Andrew D. Paterson, Jingmei Li, Gretchen L. Gierach, Christopher G. Scott, Jennifer Stone, Julie A. Douglas, Isabel dos‐Santos‐Silva, Pablo Fernández‐Navarro, Jajini Verghase, Paula Smith, Judith Brown, Robert Luben, Nicholas J. Wareham, Ruth J. F. Loos, John A. Heit, V. Shane Pankratz, Aaron D. Norman, Ellen L. Goode, Julie M. Cunningham, Mariza deAndrade, Robert A. Vierkant, Kamila Czene, Peter A. Fasching, Laura Baglietto, Melissa C. Southey, Graham G. Giles, Kaanan P. Shah, Heang‐Ping Chan, Mark A. Helvie, Andrew H. Beck, Nicholas Knoblauch, Aditi Hazra, David J. Hunter, Peter Kraft, Marina Pollán, Jonine D. Figueroa, Fergus J. Couch, John L. Hopper, Per Hall, Douglas F. Easton, Norman F. Boyd, Celine M. Vachon, Rulla M. Tamimi

Bibliographic record

VenueNature Communications · 2014
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBRCA gene mutations in cancer
Canadian institutionsOntario Institute for Cancer ResearchHospital for Sick Children
FundersU.S. National Library of MedicineMedical Research CouncilCanadian Institutes of Health ResearchNational Institutes of HealthAgency for Science, Technology and ResearchNational Institute for Health and Care ResearchCancer Research UKCampbell Family Institute for Breast Cancer ResearchNational Human Genome Research InstituteFashion Footwear Association of New YorkNational Cancer InstituteUniversity of TorontoBritish Heart FoundationDavid F. and Margaret T. Grohne Family FoundationStroke AssociationBreast Cancer Research FoundationJohns Hopkins UniversityUniversity of MichiganMcGill University
KeywordsBreast cancerGenome-wide association studyMAMMOGRAPHIC DENSITYGenetic associationBiologyQuantitative trait locusOncologyCancerMammographyGeneticsMedicineSingle-nucleotide polymorphismGenotypeGene

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.031
Threshold uncertainty score0.987

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.259
Teacher spread0.252 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations140
Published2014
Admission routes2
Has abstractno

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