Regulation of ABI5 turnover by reversible post-translational modifications
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Post-translational modifications (PTMs) such as phosphorylation, ubiquitination, and sumoylation play significant roles in regulating abscisic acid (ABA) signaling. The targets for PTM are usually transcriptional regulators such as Abscisic acid Insensitive 5 (ABI5). PTM regulate ABI5 stability as well as activity. The abundance of ABI5 is tightly controlled by the ubiquitination-26S proteasome system. E3 ubiquitin ligases such as KEG negatively regulate ABA signaling by promoting ABI5 ubiquitination and subsequent degradation by the 26S proteasome. In our recent study we demonstrated that, in the absence of ABA, KEG-mediated turnover of ABI5 occurs within the cytoplasm. Whereas ubiquitination promotes ABI5 degradation, sumoylation prohibits degradation of the transcription factor. While phosphorylation has been shown to regulate ABI5 activity, our studies and others suggest that the phosphorylation status of ABI5 does not play a significant role in modulating ABI5 turnover.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it