Morphological and electrophysiological properties of lateral entorhinal cortex layers II and III principal neurons
Bibliographic record
Abstract
The intrinsic electrophysiology and morphology of neurons from layers II and III of the lateral entorhinal cortex (EC) was investigated in a rat brain slice preparation by intracellular recording and biocytin labeling. Morphologically, we distinguished three groups of layer II principal neurons. The most numerous group included cells with multiple radiating dendrites that spread over layers II and I in a fan-like fashion. While morphologically "fan" neurons were similar to the "stellate" cells of the medial EC, electrophysiologically the fan cells lacked the persistent rhythmic subthreshold oscillations and the very pronounced time-dependent inward rectification typical of the stellate cells. The second group consisted of pyramidal cells that manifested regular spike firing and had a more negative resting potential and a longer spike duration than the fan cells. In the third group we included all those neurons that had diverse multipolar appearances distinct from the fan cells. Neurons in this group had electrophysiological profiles intermediate between those of the fan and pyramidal cells. All neurons recorded in layer III were pyramidal in shape with a basal dendritic tree that could extend into layer V and an axon that could also give off collaterals into layer V. Electrophysiologically, layer III pyramidal cells were very similar to those of layer II. On the basis of these and other data we suggest that in different EC regions layer II neurons may be conducting more input-dependent specialized processing, while cells from layer III may perform a more global or generalized function.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".