Quinone reductase inducing polyacetylenes of the Araliaceae: Effects of structure and configuration on activity
Bibliographic record
Abstract
Consumption of „indirect antioxidants“– compounds that increase the production of antioxidant proteins in vivo – is a promising means to prevent or delay diseases in which oxidative stress plays an underlying role. Indeed, indirect antioxidants show potent protective action in animal models of cancer, cardiovascular disease, Parkinson's disease and ischemia. Indirect antioxidants act by increasing the activity of Nrf2, a transcription factor responsible for the constitutive and inducible expression of antioxidant and detoxifying proteins such as quinone reductase (QR), heme oxygenase-1 and superoxide dismutase. In order to identify novel activators of Nrf2, we used the activity of the representative enzyme, QR, as a guide to isolate the active components from the methanolic extracts of two members of the Araliaceae from Canada, Oplopanax horridus and Aralia nudicaulis. Several related polyacetylenes with potent activity were isolated and a number of structure activity-relationships were observed. Importantly, the stereochemical configuration of these compounds directly impacted their relative potencies as QR inducing agents.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".