Mild encephalopathy with reversible lesion of the splenium caused by infectious endocarditis
Bibliographic record
Abstract
Mild encephalopathy with reversible lesion of the splenium of corpus callosum is a rare disease revealing mild neurological symptoms, such as disturbance, ataxia, vertigo and in some cases headache. Magnetic resonance signal alterations in the splenium of the corpus callosum can be found in patients suffering from different diseases, mostly viral infections, but also seizures, antiepileptic drug therapy, bacterial infections, hypoglycaemia, Wernicke encephalopathy, Marchiafava Bignami disease, hemolytic uremic syndrome, acute urinary retention, and acute axonal trauma. We report a 32-year old man admitted to our hospital with fever and vomiting. In the neurological examination he presented with mild dizziness and confusion. Until that time no cardiac symptoms had been reported. Due to the neurological symptoms an MR scan of the brain was performed visualizing an area of restricted diffusion with a diameter of 7 mm located in the central portion of the splenium of the corpus callosum being hyperintense on Fluid Attenuated Inversion Recovery (FLAIR) and T2-weighted turbo spin-echo images. Furthermore, multiple punctate lesions with similar appearance on diffusion weighted imaging were found in both hemispheres suspicious of embolic ischemic etiology. Consecutive transesophageal echocardiography revealed endocarditis of the mitral valve. Transient lesions of the splenium recovering within a month are not specific and there is a wide range of differential diagnoses. They may indicate severe disease despite of initially mild neurological symptoms. Pathophysiology of these lesions is not clearly understood yet, even if there exist some – however not proven – theories, such as rapidly resolving intramyelinic edema or influx of inflammatory cells associated with cytotoxic edema.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".