Communication between interstitial cells of Cajal and gastrointestinal muscle
Bibliographic record
Abstract
Interstitial cells of Cajal (ICC) pace gastrointestinal muscle by initiating slow waves in both muscle layers and appear to be preferred sites for reception of neurotransmitters. ICC of the myenteric plexus (ICC-MP) pace stomach and small intestine, while intramuscular ICC (ICC-IM) receive nerve messages. Recently, ICC-IM have been found to provide regenerative responses to and amplification of pacing messages from ICC-MP, at least in some systems. This review will examine the assumption that gap junctions provide low-resistance contacts for pacing. Structural and functional evidence will be evaluated. Structural, theoretical and experimental difficulties with the gap junctions hypothesis for pacing will be considered. So far little direct evidence about the role of gap junctions in neurotransmission exists, although a structural basis exists. Alternate possibilities for transmission of ICC pacing and neural messages will be examined and suggestions for future research made.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".