Synthesis and characterization of tritium labeled 2,3,4,9‐tetrahydro‐1<i>H</i>‐carbazoles as potent DP receptor antagonists
Bibliographic record
Abstract
Abstract Tritium labeled 2,3,4,9‐tetrahydro‐1 H ‐carbazole 1a and 2a were prepared in good yields with a specific activity of 7.0 Ci/mmol (214 GBq/mmol) and 4.2 Ci/mmol (155 GBq/mmol), respectively. Both compounds have been synthesized in high radiochemical purity by catalytic tritium–bromine exchange of the corresponding aryl bromide precursors. The 6‐bromocarbazole precursors 7 and 8 were prepared as a mixture by a three step process, involving regioselective bromination of 3c with pyridinium tribromide, oxidation of thioether 4c using m ‐CPBA and hydrolysis of acylsultamcarbazole 5c . Finally, HPLC separation of the enantiomers afforded the 6‐bromo precursors 7 and 8 in high diastereomeric ratio (dr 99% and dr 93% respectively). Copyright © 2004 John Wiley & Sons, Ltd.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".