Age-Dependent Change in a Soluble Factor Responsible for Th-2 Type of Help in the Indirect Plaque-Forming Antibody Response
Bibliographic record
Abstract
A carrier-independent type of helper activity for the indirect plaque-forming response was detected in the supernatant of spleen cell suspensions from primed mice. The potency of the factor increased during the adult life of the spleen cell donor. The factor(s) acted antigen nonspecifically and across the major histocompatibility complex. The ability of spleen cells to generate this activity was lost after treatment of primed cells with anti-Thy 1.2, anti-Lyt 1.2, or anti-Ly 7.2, in the presence of complement. The capacity to generate the activity depended on the presence of cells which adhered specifically to surfaces coated with the sensitizing antigen. The production of factor(s) involved cooperation of nonadherent T cells from primed old animals and adherent cells from unprimed donors; the age-dependent change in factor-production did not depend on the age of the donor of adherent cells.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".