Versatile Synthesis of End-Functionalized Thermosensitive Poly(2-isopropyl-2-oxazolines)
Why this work is in the frame
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Bibliographic record
Abstract
The synthesis of several end-functionalized poly(2-isopropyl-2-oxazolines) (P i PrOx) has been achieved via cationic ring-opening polymerization of 2-isopropyl-2-oxazoline. Poly(2-isopropyl-2-oxazolines) bearing primary amino groups at one chain end (Me-P i PrOx-NH 2, with M n ranging from 3600 to 9700) were obtained by conversion of hydroxyl-terminated poly(2-isopropyl-2-oxazolines) (Me-P i PrOx-OH) via phthalimide activation of the hydroxyl groups and subsequent hydrazine treatment. Heterotelechelic P i PrOx carrying an α-acetal and an ω-hydroxyl group (acetal-P i PrOx-OH) were prepared via cationic ring-opening polymerization of 2-isopropyl-2-oxazoline initiated with 3,3-diethoxy-1-propyl tosylate. The polymerizations carried out under mild conditions (40−45 °C) for extended periods of time yielded polymers of well-controlled molecular weight (MW) and narrow molecular weight distribution (MWD). Analysis of the polymers by 1 H and 13 C NMR spectroscopy, ion-exchange HPLC, and MALDI−TOF mass measurements indicated that nearly quantitative end-functionalization was achieved in all cases. Aqueous P i PrOx solutions (10 mM PBS (pH 7.4) containing 150 mM NaCl) possess a cloud point temperature near 37 °C, as determined by turbidity. Thermosensitive telechelic P i PrOx offer promising applications as smart materials including bioconjugates, hydrogels, and drug carriers.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it