Hydroxylated Polybrominated Diphenyl Ethers and Bisphenol A in Pregnant Women and Their Matching Fetuses: Placental Transfer and Potential Risks
Bibliographic record
Abstract
Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are suspected endocrine disruptors, which can pass through the mammalian placenta and accumulate in the human maternal-fetal-placental unit. However, little is known about mechanisms of placental transfer and the associated risk(s). Ten OH-PBDE congeners, bisphenol A (BPA), total 17beta-estradiol (E2), and total thyroxine (T4) were quantified in blood serum from 26 pregnant women and 28 matching fetuses, including three pairs of twins from South Korea. Only 6-OH-BDE-47, a naturally occurring OH-PBDE, was detected at relatively great concentrations (maternal serum: 17.5 +/- 26.3 pg/g ww, fetal cord blood serum: 30.2 +/- 27.1 pg/g ww), which suggests that exposure was related to diets among Korean women. Concentrations of 6-OH-BDE-47 in maternal and cord serum were positively correlated, with concentrations being significantly greater in cord blood serum. The placental transfer ratio between fetal and maternal blood serum for 6-OH-BDE-47 (F/M ratio: 1.4 +/- 1.1) was different than the observed placental transfer ratio of BPA and previously reported values for hydroxylated polychlorinated biphenyls (OH-PCBs). This result is possibly due to large affinities to T4 transport proteins. Lesser concentrations of E2 and T4 were detected in cord blood serum (E2: 4.7 +/- 2.2 ng/mL, T4: 8.5 +/- 1.7 microg/dL) compared to maternal blood serum (E2: 8.0 +/- 3.0 ng/mL, T4: 9.7 +/- 1.8 microg/dL). A major effect of OH-PBDE exposure might be a decrease in serum T4 concentrations. Potential risks associated with disruption of T4 transport to the developing fetus such as negative consequences for fetal neurological development should be considered in further studies.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.006 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".