Vasopressin Functions as an Endogenous Antipyretic in the Newborn
Why this work is in the frame
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Bibliographic record
Abstract
These experiments sought to determine the role of arginine vasopressin (AVP) in the inability of newborns to produce a fever. Our data demonstrate that the AVP analog, [1-(beta-mercapto-beta,beta-cyclopentamethylene propionic acid)-2-(O-methyl) tyrosine]arginine vasopressin (M-AVP), administered centrally to adult rats, prevented the antipyretic action of centrally injected AVP. Behaviorally thermoregulating 3-day-old rat pups failed to respond to endoxin with a fever, similar to neonates of other species, but when central AVP antipyretic receptors were blocked by pretreatment with M-AVP, the pups were able to raise their body temperature to febrile levels. The antipyretic drug, indomethacin, prevented these fevers. We conclude that endogenous AVP is a physiologically important antipyretic substance in the brain of the newborn rat.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it