D2 receptor blockade in the dorsal raphe increases quinpirole-induced locomotor excitation
Bibliographic record
Abstract
The D2/D3 dopamine receptor agonist quinpirole (QNP) produces biphasic effects on locomotion and can induce oral behaviour. To determine whether or not these behaviours result from actions of QNP at D2 receptors located in the dorsal raphe, nucleus (DRN), rats were pretreated intra-DRN with the selective dopamine D2 receptor antagonist, raclopride (0, 1 or 2 microg) prior to an acute peripheral injection of QNP (0 or 0.5 mg/kg, s.c.). Intra-DRN raclopride did not affect QNP-induced oral activity or QNP-induced locomotor inhibition. However, the high dose of raclopride potentiated QNP-induced locomotor excitation. These data suggest that D2 receptor activation in the DRN suppresses QNP-induced locomotor excitation, an effect that may be related to D2 receptor-mediated alterations in serotonin transmission.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".