Bibliographic record
Abstract
Rapid responsesIf you have a burning desire to respond to a paper published in ADC or F&N, why not make use of our "rapid response" option?Log on to our website (www.archdischild.com), find the paper that interests you, click on "full text" and send your response by email by clicking on "submit a response".Providing it isn't libellous or obscene, it will be posted within seven days.You can retrieve it by clicking on "read eLetters" on our homepage.The editors will decide, as before, whether to also publish it in a future paper issue. Hypoglycaemia and hypothermia due to nimesulide overdoseEditor-Although toxicity due to chronic administration of nimesulide has been reported, 1 2 to the best of our knowledge there is no report about poisoning due to a single ingestion.We report a 20 month old boy who accidentally took a high dose of nimesulide; 40 mg/kg, 8 times the recommended daily dosage.Physical examination was unremarkable.Laboratory findings, including hepatic and renal function, were normal, except for low to borderline glucose concentration (3.27 mmol/ l) and mild acidosis (pH 7.35, bicarbonate 16.9 mmol/l).Gastric lavage with activated charcoal was performed.One third N saline in 5% glucose (1500 ml/m 2 /day) and ranitidine were started intravenously, and he was admitted to our intensive care unit.After eight hours, serum glucose concentration was 3.44 mmol/l, venous pH 7.28 and bicarbonate 18.5 mmol/l.His systolic blood pressure and body temperature fell to 60 mm Hg and 35.0 °C (axillary), respectively.The patient was rewarmed and the intravenous infusion rate increased to 2000 ml/m 2 /day.Six hours later, his serum glucose concentration was 4.44 mmol/l, venous pH 7.33, and bicarbonate 16.5 mmol/l.Body temperature and blood pressure rose and 20 hours after admission all vital signs became normal, mild acidosis resolving within 24 hours.He was discharged after 48 hours.Physical examination and laboratory findings were normal six days after discharge.The most striking events in our patient were the development of hypotension and hypothermia.Hypothermia has been reported due to non-steroidal antiinflammatory drugs overdose, 3 but hypothermia due to the antipyretic action of nimesulide has not been reported.Nimesulide produces a dose dependent antipyretic action in rats by inhibiting COX-2 4 but its eVect under normothermic conditions is not known.Although it has been reported that nimesulide might be given to children with hypoglycaemia, 5 it may cause hypoglycaemia in high dosages.We advise frequent monitoring of vital signs and being alert for hypoglycaemia and acidosis in managing acute nimesulide overdose.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".