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Cortical malformations

2009· letter· en· W2014716431 on OpenAlexaff
Harvey B. Sarnat

Bibliographic record

VenueNeurology · 2009
Typeletter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicHedgehog Signaling Pathway Studies
Canadian institutionsAlberta Children's Hospital
Fundersnot available
KeywordsLissencephalyNeuroscienceCerebral cortexEpilepsyBrainstemBiologyMedicineGenetics

Abstract

fetched live from OpenAlex

The article by Jissendi-Tchofo et al.1 in the current issue of Neurology ® is important not only because of the new data and documentation they present, but because it puts into perspective the global concept of genetic mutations expressed as abnormal morphogenesis of the CNS. In recent years there has been a trend by some authors to describe and classify cerebral cortical malformations in a manner highly focused on the cerebral cortex, as if the rest of the brain were normal or only of secondary importance. Whereas these narrowly designed schemes may be applicable to certain special disorders, such as epilepsy, they are at best misleading and at worst become an old cliche of not seeing the forest because of the trees. The importance of thalamic, basal ganglionic, brainstem, and cerebellar malformations in association with cerebral cortical dysgeneses of genetic origin, including lissencephaly and …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.039
Threshold uncertainty score0.938

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.245
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2009
Admission routes1
Has abstractyes

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