Synthesis and Evaluation of Symmetrically PEG‐Decorated Triglycerides of Fatty Acid as Drug‐Encapsulating Agents
Bibliographic record
Abstract
New symmetrically poly(ethylene glycol) (PEG)‐decorated triglycerides of fatty acid are synthesized and proposed as drug‐encapsulation systems. A method of effective grafting of PEG on secondary hydroxy groups located on long alkyl chains by the use of a short spacer represented by succinic acid is elaborated. Synthesis of new derivatives of triacylglycerols of fatty acids (TAG) based on the triolein standard and commercial olive oil, with PEG chains of different lengths (1000, 550, and 220 Da) is performed. MTT assay on the murine macrophage cell line RAW‐262.7 shows the absence of cytotoxic effects caused by the obtained products. Encapsulation tests using itraconazole (ITZ) as a hydrophobic drug model are carried out. The influence of the PEG chain length, as well as of the presence of ITZ on the size of micelles, are studied by the dynamic light scattering (DLS) method. The reduced cytotoxicity observed on Candida albicans cells of ITZ formulated with the PEG‐decorated TAG versus the free drug indicates that the systems may be promising to increase the duration of drug release and to reduce toxic side effects. image
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".