Multiple levels of post-transcriptional control of expression of the poly (A)-binding Protein
Bibliographic record
Abstract
Regulating gene expression at the post transcriptional level allows cells to respond quickly to external conditions without remodeling the genome. This approach is advantageous for responding to growth conditions and various cellular stresses. Control of mRNA translation and stability, at the global, as well as at a specific mRNA level are important aspects of post transcriptional regulation of gene expression. Here we have discussed some general features of these two types of post transcriptional control, and reviewed our work on the translational control of poly (A)-binding protein (PABP) expression as a model of translational control of a specific mRNA. PABP itself is an important regulator of mRNA translation and stability; therefore, its own expression is tightly regulated to modulate overall protein synthesis according to growth conditions. A terminal oligopyrimidine tract and an A rich region at the 5́ UTR of PABP mRNA, control its translation in positive and negative manners respectively according to growth conditions.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".