Rosuvastatin for Tocilizumab, an Interleukin-6 Receptor Antibody-induced Dyslipidemia in a Diabetic Patient Complicated With Rheumatoid Arthritis
Bibliographic record
Abstract
Tocilizumab, which blocks interleukin-6 binding to interleukin-6 receptor, is now approved for the treatment of rheumatoid arthritis (RA). Hyperlipidemia has been reported to be one of the most common adverse effects of tocilizumab, however, the underlying mechanisms remain unknown. To understand lipid metabolism precisely, we measured plasma cytokines, small dense low-density lipoprotein (LDL), oxidized LDL and cholesterol level in each lipoprotein fraction using the high-performance liquid chromatography method before and after the tocilizumab treatment, and also studied the effect of rosuvastatin on tocilizumab-induced dyslipidemia in a diabetic patient complicated with RA. We found that rosuvastatin significantly ameliorated the tocilizumab-induced dyslipidemia. doi:10.4021/jem51w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".