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PyClone: statistical inference of clonal population structure in cancer

2014· article· en· 1,081 citations· W2015182193 on OpenAlex· 10.1038/nmeth.2883

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.
Canadian funderA Canadian agency funded it. The work may carry no Canadian affiliation at all.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.010
GPT teacher head0.398
Teacher spread
0.388 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Methods
Topic
Cancer Genomics and Diagnostics
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
BC Cancer AgencyUniversity of British Columbia
Funders
Canadian Institutes of Health Research
Keywords
BiologySomatic cellInferenceComputational biologyApproximate Bayesian computationCluster analysisPopulationGeneticsBayesian probabilitySomatic evolution in cancerStatistical inferenceEvolutionary biologyCancerGeneComputer scienceArtificial intelligenceStatisticsMathematics
Has abstract in OpenAlex
no