Tunable Aptamer Capillary Electrophoresis and Its Application to Protein Analysis
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
A tunable aptamer electrophoretic assay enables highly sensitive fluorescence detection of multiple proteins and protein isomers. The electrophoretic mobility of proteins is tuned with DNA aptamers binding to the target proteins. Fluorescently labeled aptamers of varying nucleotide lengths serve as both charge modulators for capillary electrophoresis separation and as fluorescent affinity probes for ultrasensitive laser-induced fluorescence detection. Simultaneous determination of pM levels of human immunodeficiency virus reverse transcriptase, thrombin, human immunoglobulin E, and two isomers of platelet-derived growth factor in dilute human serum demonstrates the potential applications of this assay to biomarker development.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it