Ensuring the faithful execution of cytokinesis in<i>Schizosaccharomyces pombe</i>
Bibliographic record
Abstract
Eukaryotic cells ensure error-free progress through the cell cycle by monitoring (1) the completion of cell cycle events, (2) damage to critical cellular components, or (3) structural changes such as the attachment of kinetochores to the mitotic spindle. In the presence of damage, or in the face of a reduced capacity to complete essential events, cells are capable of delaying the cell cycle so that damage can be repaired, or previous cell cycle phases can proceed to completion. Although such "checkpoints" have been extensively studied in many organisms-and much is understood with respect to the monitoring of DNA replication and DNA damage-little is known with regards to mechanisms that might monitor the completion of cytokinesis. In this review I summarize recent work from the fission yeast, Schizosaccharomyces pombe, describing the existence of regulatory modules that aid in ensuring the faithful and reliable execution of cytokinesis. Together, these modules promote the maintenance of a "cytokinesis-competent" state characterized by delayed progression into mitosis and the continuous repair and/or re-establishment of the acto-myosin ring. In this way, fission yeast cells are able to increase the likelihood of successful cell division prior to committing to a subsequent cell cycle. The recent demonstration of conservation between S. pombe components of these modules, and human proteins with defined roles in preventing cell division failure, suggest that the lessons learned in S. pombe may be applicable to other eukaryotes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".