Synthesis of three <i>Salmonella</i> epitopes for biosensor studies of carbohydrateantibody interactions
Bibliographic record
Abstract
Disaccharides 1-3 corresponding to the antigenic determinants of Salmonella serotypes A, B, and D 1 were synthesized in a form suited for use in biosensors. The disaccharide determinants each contain a unique 3,6-dideoxyhexose, namely abequose (3,6-dideoxy-D-xylo-hexose), paratose (3,6-dideoxy-D-ribohexose), and tyvelose (3,6-dideoxy-D-arabino-hexose), are α-linked to the 3-position of D-mannopyranose. The disaccharides were further derivatized with a linear aglycon that has a terminal amino group, and can be readily coupled to pertinent chains carrying a terminal thiol for the construction of self-assembled monolayers (SAMs). Efficient routes that employed a single 3,6-dideoxygenation step were developed for the synthesis of paratoside 15 and tyveloside 22.Key words: Salmonella O-antigens, lipopolysaccharide, abequose, paratose, tyvelose, 3,6-dideoxyhexose, deoxygenation, glycoside tethers, immobilization via pentenyl glycosides.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".