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Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

2012· article· en· 961 citations· W2016370312 on OpenAlex· 10.1038/ng.1076

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.006
GPT teacher head0.212
Teacher spread
0.206 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Genetics
Topic
T-cell and B-cell Immunology
Field
Immunology and Microbiology
Canadian institutions
University of TorontoUniversity Health NetworkMount Sinai Hospital
Funders
National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of General Medical SciencesWellcome Trust
Keywords
Major histocompatibility complexRheumatoid arthritisHuman leukocyte antigenBiologyImputation (statistics)Single-nucleotide polymorphismSNPGeneticsAlleleImmunologyHaplotypeGenome-wide association studyGeneAntigenGenotype
Has abstract in OpenAlex
no