Tyrphostins inhibit lipopolysaccharide induced preterm labor in mice
Bibliographic record
Abstract
OBJECTIVE: We tested whether lipopolysaccharide (LPS)-induced murine preterm birth was delayed by tyrphostins (inhibitors of tyrosine kinases). STUDY DESIGN: The tyrphostins, AG126 or AG1288, or the prostaglandin endoperoxide H synthase-2 (PGHS-2) inhibitor, NS-398, were administered 2 h before LPS, with LPS, or 2 h after LPS and their effect on gestational length was measured. RESULTS: Only tyrphostins and NS-398 administered 2 h before LPS successfully delayed preterm birth (p < 0.05). CONCLUSIONS: Both tyrphostins AG126 and AG1288 as well as NS-398 inhibited LPS induced preterm birth to the time of normal birth.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".