Use of biclustering for missing value imputation in gene expression data
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
DNA microarray data always contains missing values. As subsequent analysis such as biclustering can only be applied on complete data, these missing values have to be imputed before any biclusters can be detected. Existing imputation methods exploit coherence among expression values in the microarray data. In view that biclustering attempts to find correlated expression values within the data, we propose to combine the missing value imputation and biclustering into a single framework in which the two processes are performed iteratively. In this way, the missing value imputation can improve bicluster analysis and the coherence in detected biclusters can be exploited for better missing value estimation. Experiments have been conducted on artificial datasets and real datasets to verify the effectiveness of the proposed algorithm in reducing estimation errors of missing values.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it