Molecularly Imprinted Polypyrrole Encapsulated Carbon Nanotubes in Stainless Steel Frit for Micro Solid Phase Extraction of Estrogenic Compounds
Bibliographic record
Abstract
A novel micro-solid phase extraction (microSPE) device was prepared by electrochemically adhering molecularly imprinted polypyrrole encapsulated carbon nanotubes (MIPPy/CNTs) onto a stainless steel frit. It was found that the use of CNTs increased the total binding capacity without compromising the porosity of the frit. Three templates, 17alpha-ethynyl estradiol (EE2), 17beta-estradiol (E2), and ochratoxin A (OTA) were imprinted individually to make their respective MIPPy/CNTs-modified frits. The binding properties of these microSPE devices were characterized by high performance liquid chromatography (HPLC) with fluorescence detection (FLD). In comparison with non-imprinted polypyrrole encapsulated carbon nanotubes (PPy/CNTs), the molecular imprinting technique enhanced the selective binding towards the imprint molecules. MIPPy/CNTs-microSPE-HPLC-FLD results demonstrated the selectivity of MIPPy had been tailored by imprinting with different templates. This is the first report on how versatile pyrrole can be as a functional monomer for the molecular imprinting of target compounds with a broad range of high to low pKa values.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".