Shifting the paradigm for maintenance therapy in advanced non-small-cell lung cancer
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Shifting the paradigm for maintenance therapy in advanced non-small-cell lung cancer Barbara MeloskyUniversity of British Columbia, Vancouver, BC, CanadaAbstract: The standard of care in metastatic non-small-cell lung cancer (NSCLC) is to treat patients with a platinum doublet for 4 to 6 cycles and to offer second-line therapy upon progression. Maintenance therapy in NSCLC is defined as a therapeutic agent which is administered after first-line chemotherapy is complete, but before the disease progresses. While maintenance therapy is not yet universally accepted as a therapeutic approach, emerging data have demonstrated its potential to improve progression-free survival and overall survival in a clinically significant way. In this article a concise recent review of data related to the role of maintenance therapy in patients with advanced NSCLC is provided, complementing previous information in the field. It is recommended that NSCLC patients are offered maintenance therapy after first-line therapy is complete.Keywords: advanced non-small-cell lung cancer, maintenance therapy, pemetrexed, erlotinib
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it