Immobilized DNA biosensor based on evanescent wave long-period fiber gratings
Bibliographic record
Abstract
A DNA aptamer sensor using a long-period grating (LPG) is proposed for the sensitive detection of the interaction between the DNA aptamer and its target. The DNA aptamer can be immobilized on the surface of the LPG, and the detection of the specific interaction between the DNA aptamer and its target is monitored optically. This sensor operates on the evanescent field interacting with the DNA aptamer immobilized over the grating region. The reaction between the DNA aptamer and its target alter the refractive index and thus change the LPG transmission spectrum, which can be monitored in real time. This technology eliminates the labeling of the DNA aptamer. In this paper, for the first time, the dependence of the LPG transmission spectrum on the characteristic of the LPG and the property of the immobilized DNA aptamer are studied both theoretically and experimentally. Experimental demonstration of the immobilization of DNA aptamer on LPG and its real-time effect on the transmission spectrum are reported.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".