Maternal–Fetal Relationships in Corticosteroid Metabolism
Bibliographic record
Abstract
Corticosterone in fetal mouse tissues after injection of mothers with 14C-corticosterone was determined by acetylation with 3H-acetic anhydride and cocrystallization to constant specific activity. The corticosterone content of whole fetal tissue varied between gestational days 13 and 17 from 641 to 300 ng/g. Specific activity of fetal hormone remained essentially constant; after a 15-min pulse this was as much as one-quarter that of maternal hormone. Placenta, head and liver showed distinctly different patterns which changed during this time, with a decrease in conversion of corticosterone to 11-dehydrocorticosterone. A sharp increase occurred in the activity of fetal liver 11beta-hydroxysteroid:NADP oxidoreductase activity. This mitochondrial enzyme, pH optimum 6, KM = 33 micrometer, reduced the metabolite, raising the relative amount of corticosterone in the fetus from 16 to 91%. 1 day after removal of maternal adrenals both maternal and fetal corticosterone were normal, indicating ability of fetal adrenals to function. Maternal corticosterone, however, crossed the placenta readily and it is considered likely that, normally, the maternal hormone predominates. Regardless of origin, corticosterone is maintained by enzymatic conversion in a distinct manner in different tissues.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".