Synthesis of α,ω-Dimercapto Poly(<i>N</i>-isopropylacrylamides) by RAFT Polymerization with a Hydrophilic Difunctional Chain Transfer Agent
Why this work is in the frame
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Bibliographic record
Abstract
A new hydrophilic difunctional reversible addition−fragmentation chain transfer (RAFT) agent, diethylene glycol di(2-(1-isobutyl)sulfanylthiocarbonylsulfanyl-2-methylpropionate) (DEGDIM ) was synthesized and shown to be effective in imparting living characteristics to the radical polymerization of N -isopropylacrylamide (NIPAM), providing a route to telechelic poly( N -isopropylacrylamides) (PNIPAM) of predictable molecular weights and narrow molecular weight distributions. The thiocarbonylthio end groups were transformed into thiol groups via aminolysis with near quantitative yields, as determined by a thiol-specific quantitative UV absorbance assay. By using a pyrene-substituted initiator, bis( N -(1-pyrenylbutyl))-4,4‘-azobis-(4-cyanopentanamide) (BPAC), it was found that the amount of initiator-derived polymer chains in the DEGDIM mediated polymerization of NIPAM was negligible (∼1%) compared to the amount of polymer chains derived from DEGDIM, the difunctional chain transfer agent. These results support the theoretical calculations and confirm the high purity of α,ω-dithiol telechelic hydrosoluble polymers prepared by the RAFT polymerization process.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it