Selective dehybridization of DNA–Au nanoconjugates using laser irradiation
Bibliographic record
Abstract
Plasmonic heating to trigger release of oligonucleotides from nanoconjugates is potentially useful for therapeutic purposes and designed assembly of DNA nanostructures. In the past, great controllability has been achieved by introducing distinctive absorption nanoparticle centers, where the anchoring bond (e.g., sulfur-gold bond) has been selectively broken. Instead of releasing the surface-bound duplex DNA via breakage of the gold-sulphur anchor bond, selective and non-destructive dehybridization of DNA under a "mild" condition on different gold nanoconjugates is demonstrated in this work. This finding will permit sequential dehybridization/release of DNA at specific regions of a complex system; thus it can be extended to control gene expression and to manipulate an assembly of highly organized DNA constructs. Particularly we show herein the feasibility of selectively dehybridizing DNA-Au nanoconjugates via localized plasmonic heating, which is accomplished by controlling the laser wavelength, power, and irradiation time.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".