Indicator amino acid oxidation (1‐ <sup>13</sup> C‐phenylalanine) is not affected by day of adaptation (1, 3 or 7d) to a wide range of lysine intake in young men
Bibliographic record
Abstract
Our indicator amino acid oxidation (IAAO) method uses a short term adaptation (1d) to determine amino acid requirements. Our objective was to examine whether a prolonged adaptation period caused significant changes in oxidation of the indicator amino acid, 1‐ 13 C‐phenylalanine. Three, healthy, male subjects randomly received each of the 4 test lysine intakes (5, 20, 35 and 70 mg/kg/d) for 7‐d. IAAO studies were conducted on d1, 3 and 7 with breath and blood samples collected at baseline and isotopic steady state. The experimental diet was isocaloric and isonitrogenous, with protein supplied at 1.0 g/kg/d based on egg protein composition. Data was analyzed by mixed‐models ANOVA with repeated measures. 13 C‐phenylalanine oxidation ( F 13 CO2, μmol/kg/hr) due to adaptation Phenylalanine oxidation ( F 13 CO 2 ) was not significantly different within 1, 3 or 7 d of adaptation for any of the lysine intakes. Thus, adaptation to longer periods does not affect the derived estimates of dietary amino acid requirements. (CIHR supported).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".