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Record W2019726944 · doi:10.3109/10428190903297531

Decreased major histocompatibility complex class II expression in diffuse large B-cell lymphoma does not correlate with CpG methylation of class II transactivator promoters III and IV

2009· letter· en· W2019726944 on OpenAlexaff
Sarah T. Wilkinson, Diane R. Fernandez, Shawn P. Murphy, Rita M. Braziel, Elı́as Campo, Wing C. Chan, Jan Delabie, Randy D. Gascoyne, Louis M. Staudt, Elaine S. Jaffe, Andreas Rosenwald, Lisa M. Rimsza

Bibliographic record

VenueLeukemia & lymphoma/Leukemia and lymphoma · 2009
Typeletter
Languageen
FieldMedicine
TopicLymphoma Diagnosis and Treatment
Canadian institutionsBC Cancer AgencyUniversity of British Columbia
FundersNational Cancer InstituteUniversity of ArizonaAmerican Cancer Society
KeywordsMethylationCIITACpG siteTransactivationLymphomaPromoterDiffuse large B-cell lymphomaDNA methylationBiologyCancer researchMajor histocompatibility complexCD74ImmunologyMHC class IIGeneGeneticsGene expression

Abstract

fetched live from OpenAlex

Diffuse large B-cell lymphoma (DLBCL) is a disease marked by heterogeneity in clinical presentation, morphology, and underlying biology. Importantly, this translates into variability of patient res...

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0040.002
Insufficient payload (model declined to judge)0.0040.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.228
Teacher spread0.217 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2009
Admission routes1
Has abstractyes

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