Coupling ALE Technique and Harmonic Parametrization to Describe Concurrent and Successive Elementary Cell Deformations
Bibliographic record
Abstract
We present here an extension of our finite element model of the Drosophila embryo to consider the interdependence of successive morphogenetic movements. A novel approach is used, which couples the Arbitrary Lagrangian Eulerian formulation with the harmonicparametrization. The combination of the two techniques allows to constantly update the deforming embryo geometry and simultaneously build an associated system of curvilinear coordinates. Thus, we are able to exactly describe the elementary cell deformations responsible for each biological event that are then defined with respect to the dynamic middle surface of the embryonic tissue and to their relative reference configuration. Both the active and the passive deformations occurring to the cells are considered through the deformation gradient decomposition. We develop a concurrent simulation of three morphogenetic movements: the ventral furrow invagination, the cephalic furrow formation and the germ band extension. The results show a consistent similarity with respect to the physical phenomena. More generally, the numerical approach that we propose could constitute a powerful tool to rigorously describe and simulate complex shape changes in biological systems.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".