Inhibition by Calcium of the Cyclic AMP-Mediated Stimulation of Thymic Lymphoblast Proliferation by Prostaglandin E<sub>1</sub>
Why this work is in the frame
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Bibliographic record
Abstract
During the first 10 min after exposure of rat thymic lymphocytes (thymocytes) to a high concentration (5.0 µg/ml) of prostaglandin E1 (PGE1) in medium without added calcium, there is a 67-fold rise in the cellular cyclic AMP content which causes strong stimulations of deoxyribunucleic acid (DNA) synthesis and cell proliferation. On the other hand, in the presence of 1.0 mM calcium, PGE1 causes a similar (68-fold) rise in the cellular cyclic AMP content and a strong stimulation of DNA synthesis, but the stimulated cells do not enter mitosis. Thus, calcium selectively inhibits the cyclic AMP-induced mitogenic process.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it