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Record W2020509895 · doi:10.1115/imece2008-68831

Multi-Step Dynamic Control for Enhanced Electrokinetic Transport Characteristics in Microchip Capillary Electrophoresis

2008· article· en· W2020509895 on OpenAlex
Zhanjie Shao, Carolyn L. Ren, G. E. Schneider

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueVolume 13: Nano-Manufacturing Technology; and Micro and Nano Systems, Parts A and B · 2008
Typearticle
Languageen
FieldEngineering
TopicMicrofluidic and Capillary Electrophoresis Applications
Canadian institutionsUniversity of Waterloo
Fundersnot available
KeywordsElectrokinetic phenomenaSpark plugMicrofluidicsElectrophoresisDiffusionMaterials scienceSeparation (statistics)Capillary electrophoresisSample (material)Capillary actionComputer scienceBiological systemChromatographyChemistryNanotechnologyMechanical engineeringEngineering

Abstract

fetched live from OpenAlex

A numerical model has been developed and is used to study the loading and dispensing processes in on-chip cross-linked microchannels. The electrokinetic transport characteristics and the roles of species’ electrophoretic mobilities and diffusion coefficients on the electrokinetic flow are revealed. A study is also performed on an implementation of multi-stage injection. The study of conventional one-step injection and separation is performed and helps construct a distinct understanding of the processes. Species movement and sample plug development with diffusion are examined; results include concentration profiles and contour plots over a range of injection and separation time. Real-time monitoring of different species’ movements is performed for injection guidance. Some limitations of the separation process are presented with potential solutions, such as the removable tail effect and exceptional quick diffusion. Using innovative dynamic control, efforts are made to control the flow and species transport for improved sample plugs, which is key to achieving excellent electrophoretic separation. Through a series of multi-step injection schemes, four typical sample plugs are produced with specific attributes such as reduced dispersion leakage, desirable sample plug size, enhanced shape, etc. Comparisons of conventional and the proposed methods are performed. Typical resulting sample plugs are evaluated using the two developed parameters of resolution and detectability for numerically simulated separation processes. Depending on requirements, one can generate some specific sample plugs through this multi-step dynamic injection method. The resulting understanding will assist in the design of microfluidic devices for separation by providing insight into the process influences and controls and by identifying areas for further research.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.075
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.183
Teacher spread0.179 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it