Well-Defined Galactose-Containing Multi-Functional Copolymers and Glyconanoparticles for Biomolecular Recognition Processes
Bibliographic record
Abstract
We report here the syntheses of galactose-containing polymers via reversible addition−fragmentation chain transfer process. Diblock copolymers with one galactose-containing chain segment and one primary amine-containing or linear glucose-containing chain segment were prepared via chain extension technique. Primary amine pendant groups of the copolymer were further modified with biotinyl- N -hydroxysuccinimide ester. Subsequently, multifunctional glyconanoparticles were prepared and used in the study of biomolecular recognition processes. The biomolecular recognition of the biotin and galactose moiety on the surface of the glyconanoparticles toward avidin and Ricinus communis agglutinin lectin respectively was confirmed using UV−visible spectroscopy and diffractive optics techniques. It was found that both carbohydrate-carbohydrate and carbohydrate−protein interactions increased with increasing divalent salt (Ca 2+ and Mn 2+ ) concentration.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".