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The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus

2006· article· en· 710 citations· W2020808135 on OpenAlex· 10.1016/j.neuron.2006.07.006

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
ObservationalBench or experimentalTheoretical or conceptualNot applicable
Classifier consensus
Observational
Teacher imitation scores

Codex

Bench or experimental0.100
Other design0.048
Observational0.044
Not applicable0.044
Randomized trial0.003
Theoretical or conceptual0.002
Case report0.001
Metaresearch0.001
Systematic review0.001
Scholarly communication0.000
Research integrity0.000
Simulation or modelling0.000
Open science0.000
Qualitative0.000
Meta-epidemiology (narrow)0.000
Bibliometrics0.000
Science and technology studies0.000
Non-randomized trial0.000
Meta-epidemiology (broad)0.000
Meta-analysis0.000

Gemma

Observational0.322
Theoretical or conceptual0.040
Not applicable0.034
Bench or experimental0.003
Randomized trial0.002
Case report0.001
Metaresearch0.000
Simulation or modelling0.000
Science and technology studies0.000
Research integrity0.000
Qualitative0.000
Scholarly communication0.000
Open science0.000
Meta-analysis0.000
Non-randomized trial0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Bibliometrics0.000
Systematic review0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.011
GPT teacher head0.255
Teacher spread
0.244 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Balanced control of neuronal activity is central in maintaining function and viability of neuronal circuits. The endocannabinoid system tightly controls neuronal excitability. Here, we show that endocannabinoids directly target hippocampal glutamatergic neurons to provide protection against acute epileptiform seizures in mice. Functional CB1 cannabinoid receptors are present on glutamatergic terminals of the hippocampal formation, colocalizing with vesicular glutamate transporter 1 (VGluT1). Con…

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